Sensory integration can be described as the process of taking in information from external stimuli (taste, touch, etc.), processing that information, and reacting accordingly. Down syndrome leads to varying degrees of sensory integration dysfunctions and needs to be addressed appropriately. When the brain responds in an atypical way, it produces a hyporesponsive (the brain fails to register inputs) or hyperresponsive (the brain registers inputs too intensely) reaction. Many children with T21 may be hyporesponsive for one type of input, and hyperresponsive for another. Through providing the appropriate sensory input, the child can begin to register and interpret information in a normal way. In addition to sensory integration therapy, there are some activities that can be done with a child to help.

- Physical Exercise - Having the child move themselves or having something move them (eg. swing) causes the child to have to respond to their change in position.

- Have the child lie on multiple different materials.

- Wrap the child tightly in a blanket or sheet- it also works their muscle development if they work their way out of the roll.

- Tow the child on a blanket or pillow- if the child is able, have them hold onto a rope while being pulled across a smooth floor.

- Something to fiddle with- having a stress ball or other moldable object can also help the child focus.

- Covering the child in stuffed animals of pillows and letting them crawl out.

- Having the child play in a box filled with stuffed animals.

- Massage the child.

- Give the child a bath.